Blar i forfatter "Vik, Jørg"

Viser treff 1-3 av 3

    • Differential prognostic impact of platelet-derived growth factor receptor Expression in NSCLC 

      Kilvær, Thomas Karsten; Rakaee, Mehrdad; Hellevik, Turid; Vik, Jørg; de Petris, Luigi; Dønnem, Tom; Strell, Carina; Østman, Arne; Busund, Lill-Tove; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-15)
      Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of stromal PDGFR expression remains uncertain. Tumor specimens from 553 patients with primary operable stage I-IIIB NSCLC was obtained and tissue micro-arrays (TMA) ...

    • Ionizing radiation abrogates the pro-tumorigenic capacity of cancer-associated fibroblasts co-implanted in xenografts 

      Grinde, Maria Tunset; Vik, Jørg; Camilio, Ketil Andre; Martinez-Zubiaurre, Inigo; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-25)
      Cancer-associated fibroblasts (CAFs) are abundantly present in solid tumors and affect tumorigenesis and therapeutic responses. In the context of clinical radiotherapy, the impact of irradiated CAFs to treatment outcomes is largely unexplored. Aiming at improving radiotherapy efficacy, we have here explored the effect of radiation on the inherent pro-tumorigenic capacity of CAFs in animals. Ionizing ...

    • Synergistic effects of Radiotherapy and Immune Checkpoint Inhibitors in Cancer Treatment 

      Vik, Jørg (Master thesis; Mastergradsoppgave, 2016-05-31)
      Background: Use of immune checkpoint inhibitors have improved survival in patients suffering from cancer types such as advanced melanoma and NSCLC. Through increased understanding of immunological reactions associated with radiotherapy, a potential for synergy of radiotherapy and immune checkpoint inhibitors has emerged. Preclinical proof-of-concept studies have confirmed synergy of the treatments ...